Alzheimer's disease is dramatically
increasing: if 4% of the cases are due to genetic reasons, the rest 96% are due
to causes that rest unknown.
There are no effective therapies available,
so far; just some symptomatic treatment. As the disease seems to be
multifactorial, Alzheimer's research has started investigating its risk
Alzheimer's research is exploring possible interventions on the causes in order
to operate during the phase in which the disease does not show its symptoms,
with the purpuse of delaying the appearing of Alzheimer's symptomps and,
therefore, opposing the onset and progression of the disease itself.
According to pre-clinical studies, brain
cellular and molecular alterations appear long before symptoms show themselves
but remain to be known molecular and cellular mechanisms on which these
alterations operate and, above all, possible therapeutic interventions time
The core of Alzheimer's research is, thus, represented by investigations on the
disease development before cognitive symtoms appear, in order to explore
histopathological aspects so far little-known and hypothesize a causative role
in the progression of the disease.
The research results will represent the
firs step in finding out countermeasures, both pharmaceutical and non, aimed at
slowing down Alzheimer's natural development.